NuOss natural cancellous and cortical bone matrix is produced by the removal of all organic components from bovine bone. Due to its natural porous structure, NuOss is physically and chemically comparable to the mineralized matrix of human bone. The proprietary manufacturing process of NuOss allows for maintenance of the naturally occurring bone mineral structure, including macroscopic and microscopic structures. Due to this trabecular architecture with interconnecting macro and micro pores, the ingrowth of new bone and associated vascularization at the grafting site is optimized. NuOss may be used with autogenous bone where there is an insufficient quantity of bone to fulfill the needs of the proposed surgical procedure.
Just like NuOss granules, naturally structured NuOss Collagen combines the mineral properties of cancellous particulate with the space maintenance of collagen. This highly manageable combination provides a convenient approach to filling periodontal and maxillofacial defects. With NuOss Collagen products, there is no mixing or loose handling.

1. 2019 U.S. Market Report Suite for Dental Bone Graft Substitutes and Other Biomaterials; iDATA_USDBGS19_MS (pages 37, 130-131, 133, 152 and 158).
2. Klenke FM, Liu Y, Yuan H, Hunziker EB, Siebenrock KA, Hofstetter W. Impact of pore size on the vascularization and osseointegration of ceramic bone substitutes in vivo. J Biomed Mater Res A. 2008 Jun 1;85(3):777-86.