Electronic 222 Ordering (e222)

Electronic 222 Ordering (e222)

Schedule II Drug Ordering

There are 2 ways to place a schedule II drug order:

1. If you are enrolled in e222 with Henry Schein:

*To enroll in e222 with Henry Schein Click here.

2. Place your order using DEA Form 222 and mail to:

Henry Schein, Inc.
5315 West 74th Street, Suite 300
Indianapolis, IN 46268

For more information on schedule II drug ordering call: 1-800-532-0766.

Henry Schein e222 Overview

In an effort to reduce errors, increase efficiencies, and expedite the transaction of ordering controlled substances, the Drug Enforcement Administration (DEA) developed the Controlled Substance Ordering System (CSOS). CSOS allows for buyers and sellers of controlled substances to be able to transact securely and electronically without the use of manual paper work (i.e., DEA Form 222). In order to utilize the DEA’s CSOS program, each individual purchaser must enroll with the DEA to acquire a CSOS digital certificate. Once the individual is enrolled with the DEA and the digital certificate is installed on the individual’s computer, schedule II drugs can be ordered from Henry Schein using our CSOS compliant, electronic schedule II ordering system (e222).

e222 Interactive Enrollment Process Map

e222 Enrollment Information

1. For DEA questions about CSOS enrollment, call 1-877-332-3266 (8AM–6PM EST) or visit www.deaecom.gov/applycert.html for more information.
2. For assistance enrolling into e222 with Henry Schein, submit our e222 enrollment form or call 1-800-532-0766.
3. Once enrolled in Henry Schein’s e222 program, visit e222sm.henryschein.com to place your e222 order. If you have technical problems while placing an e222 order, please call our e222 Technical Support Line at 1-254-933-4452 (8AM-8PM EST) for assistance or support@legisym.com.

Please Note: According to the DEA CSOS Registration Authority, applicants can expect to receive their certificate activation notices on average about one month after mailing the application package to the DEA — incomplete applications will take longer to process.

Additional e222 Resources

Guidance selecting the appropriate CSOS Application to submit:
Choosing The Appropriate DEA (CSOS) Application

Help Installing, exporting, and managing your CSOS digital security certificate:
CSOS Certificate Support Guide

Customers who have completed CSOS registration and the digital security certificate/e-mail test can enroll in e222 electronically:
Henry Schein e222 Enrollment Request Form

DEA answers for the most common CSOS-related questions:
CSOS Frequently Asked Questions