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Electronic 222 Ordering (E222)

Electronic 222 Ordering (E222)

Henry Schein Electronic Ordering 222 Overview

In an effort to reduce errors, increase efficiencies, and expedite the transaction of ordering controlled substances, the Drug Enforcement Administration (DEA) developed the Controlled Substance Ordering System (CSOS). CSOS allows for buyers and sellers of controlled substances to be able to transact securely and electronically without the use of manual paper work (i.e., DEA Form 222). In order to utilize the DEA's CSOS program, each individual purchaser must enroll with the DEA to acquire a CSOS digital certificate. Once the individual is enrolled with the DEA and the digital certificate is installed on the individual's computer, Schedule II drugs can be ordered from Henry Schein using our CSOS compliant, electronic schedule II ordering system (e222).

Electronic Ordering 222 Enrollment Information

  1. For DEA questions about CSOS enrollment, call 1-877-332-3266 (8AM–6PM EST) or visit for more information.
  2. For assistance enrolling into Electronic Ordering 222 with Henry Schein, submit our e222 enrollment form or call 1-800-532-0766.
  3. Once enrolled in Henry Schein's e222 program, visit to place your e222 order. If you have technical problems while placing an e222 order, please call our e222 Technical Support Line at 1-254-933-4452 (8AM-8PM EST) for assistance or

Please Note: According to the DEA CSOS Registration Authority, applicants can expect to receive their certificate activation notices on average about one month after mailing the application package to the DEA—incomplete applications will take longer to process.